An international research team has discovered that certain ingredients in green tea and red wine can prevent the formation of toxic metabolites, and is expected to be used in the treatment of genetic metabolic diseases such as phenylketonuria in the future.
Phenylketonuria is a hereditary metabolic deficiency disease. The abnormal metabolism of specific amino acids in the patient's body causes abnormal deposition of toxic amyloid, which affects the development of the brain and nervous system, resulting in severe mental retardation.
An international research team led by Tel Aviv University in Israel published a paper in the online version of the British Journal of Communications Chemistry. They said that they tested genetic metabolic diseases such as phenylketonuria with the polyphenolic active ingredient EGCG in green tea and tannic acid in red wine The metabolites in chrysanthemum are related to the formation of toxic amyloid. The results show that EGCG and tannic acid can effectively block the formation of such proteins.
Previous studies have shown that the above two components can also help prevent the deposition of toxic amyloid in the brain of some elderly patients, such as Alzheimer's disease and Parkinson's disease.
The researchers said that this research will help to understand the role and importance of metabolites in metabolic diseases, neurodegenerative diseases and even cancer. In the future, it is expected to develop related treatments to help patients with these diseases.
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