A research group at the Advanced Research Institute for Atomic and Molecular Materials (AIMR) at Tohoku University in Japan developed a technique for vertically aligning carbon nanotubes (CNTs) on a cell culture substrate material. It has been said that it has been confirmed that about 40 times the horizontal conductivity can be obtained. When this material is used to culture myocytes, myocyte differentiation and maturation efficiency are improved. The technology is expected to be used in a wide range of applications such as regenerative medicine and biosensors. The results were published on the online version of Scientific Reports on March 19, 2014.
Sheet manufacturing method
As a technology that can support regenerative medicine, it has become increasingly important to develop a matrix material that can three-dimensionally promote cell-cell adhesion and cell steric attachment. Among them, attempts to develop biomaterials using a "Hydrogel" having biocompatibility and containing a large amount of water molecules are very popular.
Northeastern University has developed a technology for vertically aligning CNTs on a matrix material of gelatin-methyl methacrylate graft copolymer (GelMA). This technology first introduces a GelMA gelatin precursor and CNTs between a plate-shaped transparent electrode made of ITO (Indium Tin Oxide) and a strip-like transparent electrode, and applies an electric field in the vertical direction. At this point, the CNTs are aligned in the vertical direction due to the dielectrophoretic force generated along the ITO electrodes. By irradiating the ultraviolet light in this state, the cross-linked gel is cured, and the CNT vertically aligned hydrogel sheet can be produced.
Testing of the conductivity of this CNT-GelMA hydrogel hybrid material showed that the value of the gel in the vertical direction was said to be about 40 times higher than the horizontal direction. In addition, the mechanical strength was also superior to that of the CNT hydrogel sheet in which the hydrogel sheet monomers and the CNTs were arranged in an unordered manner.
The team confirmed that as the conductivity increases, the efficiency of cell culture has also increased. When myoblasts (C2C12) were cultured on CNT vertical-aligned hydrogel sheets and electrical stimulation was performed, more myeloid cells than the original method were obtained. (Author: Junichi at large, the Nikkei online technology feeds!)
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